Week 4.2 Prompt: Read the following scientific paper:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539371/(don’t need read entire paper [although I encourage you to do so], skim it and focus on the parts that will help you achieve the learning objectives[questions below])Is this scientific paper is expert opinion, a review article (lit or systematic), primary scientific research or a meta-analysis?Briefly provide a video, diagram or figure that highlights the pathophysiology of osteoporosis and give a brief summary of the what you posted.Look at figure 2, and annotate it. Tell me what type of molecules are estrogen and testosterone (what macromolecule class, are they enzymes? signaling molecules (if so which type of signaling?) and annotate the effects they have on the different cell types highlighted in the figure (osteoblast, HSC, osteoclasts, osteocytes, mesenchymal stem cells, etc) if any.Look at figure 8, and explain the proposed biphasic nature of estrogen on bone growth and development (can explain in a paragraph, by providing an annotated upload of figure 8 or the most effective way using both).After reading about the role of sex steroid replacement in the treatment of osteoporosis what are the benefits and the potential adverse effects (unwanted effects) of recommending them to a patient for which you would be on the care team?
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